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      Stibogluconate (sodium)

      發(fā)布日期:2017-10-26   瀏覽次數(shù):0
      核心提示:a href=https://www.medchemexpress.com/Stibogluconate-sodium.htmlStibogluconate (sodium)/a產(chǎn)品描述:Stibogluconate sodium
      <a href="https://www.medchemexpress.com/Stibogluconate-sodium.html">Stibogluconate (sodium)</a>產(chǎn)品描述:Stibogluconate sodium is  is a potent inhibitor of PTPases Src homology PTPase1 (SHP-1), SHP-2, and PTP1B, inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10 μg/ml, 100 μg/ml respectively.

      target: SHP-1, SHP-2, PTP1B.[1]

      In vitro: Stibogluconate sodium inhibits protein tyrosine phosphatases. Stibogluconate sodium targets the SHP-1 PTPase catalytic domain and forms stable complexes with the phosphatase. Stibogluconate sodium induces tyrosine phosphorylation of cellular proteins and augments IL-3-induces Jak2/Stat5 phosphorylation in Baf3 cells. Stibogluconate sodium augments IL-3-induced cell proliferation of Baf3 cells. [1]

      In vivo: SSG induces 61% growth inhibition of Renca tumors in BALB/c mice coincident with an increase (2-fold) in tumorinfiltrating macrophages (M). [2]

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      已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接:<a href="http://www.medchemexpress.cn/stibogluconate-sodium.html">www.medchemexpress.cn/stibogluconate-sodium.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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