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      NIH-12848研究進(jìn)展
      
                
      
                發(fā)布日期：2017-10-30                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/NIH-12848.htmlNIH-12848/a產(chǎn)品描述：NIH-12848 is a putative phosphatidylinositol 5-
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/NIH-12848.html">NIH-12848</a>產(chǎn)品描述：NIH-12848   is a putative phosphatidylinositol 5-phosphate 4-kinase γ   (<b>PI5P4Kγ</b>) inhibitor with an   <b>IC<sub>50</sub></b> of 1 μM.
      
            
      
            IC50 & Target: IC50: 1 μM (PI5P4Kγ)<sup>[1]</sup>
      
            
      
            <i><b>In Vitro:</b></i> NIH-12848 inhibits PI5P4Kγ   with an IC<sub>50</sub> of approximately 1 μM but does not   inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848   inhibits the translocation of Na<sup>+</sup>/   K<sup>+</sup>-ATPase to the plasma membrane that occurs when   mpkCCD cells grow to confluence and also prevents reversibly their forming of   ‘domes’ on the culture dish. Both these NIH-12848-induced effects are   mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or   β. NIH-12848 could be a potentially powerful tool for exploring the cell   physiology of PI5P4Ks<sup>[1]</sup>. 
      
            
      
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            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫(kù)，總部位于美國(guó)新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營(yíng)銷網(wǎng)點(diǎn)遍及全球20多個(gè)國(guó)家地區(qū)。MCE經(jīng)過(guò)多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過(guò)4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過(guò)20種不同類型的化合物庫(kù)，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。</span>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">MCE   定期增加各領(lǐng)域熱門抑制劑、激動(dòng)劑，不斷擴(kuò)增已有化合物庫(kù)，以滿足最新的科研需求；</span>
      
            <br style="color: rgb(62,62,62);font-family: "Helvetica   Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;line-height: 22.0px;background-color: rgb(251,251,251);">
      
            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">數(shù)千種產(chǎn)品在上海有充足備貨，24-48小時(shí)內(nèi)送達(dá)客戶；</span>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">大量產(chǎn)品提供免費(fèi)試用裝；</span>
      
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            已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/nih-12848.html">www.medchemexpress.cn/nih-12848.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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